Choline metabolism in malignant transformation
نویسندگان
چکیده
منابع مشابه
Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells.
Transduction of mitogenic signals in cells can be mediated by molecules derived from the synthesis and breakdown of the major membrane phospholipid, phosphotidylcholine. Studies were performed on human mammary epithelial cells in culture to understand the impact of malignant transformation and progression on membrane phospholipid metabolism. In the model system used here, phosphocholine levels ...
متن کاملPhospholipid Metabolism of Human Mammary Epithelial Cells Malignant Transformation Alters Membrane Choline
Transduction of mitogenic signals in cells can be mediated by molecules derived from the synthesis and breakdown of the major membrane phospholipid, phosphotidylcholine. Studies were performed on human mammary epithelial cells in culture to understand the impact of malignant transformation and progression on membrane phospholipid metabolism. In the model system used here, phosphocholine levels ...
متن کاملImmortalization and transformation are associated with specific alterations in choline metabolism.
Analysis of transformed, immortalized, and primary rat Schwann cells by high-resolution proton nuclear magnetic resonance spectroscopy reveals that immortalization of Schwann cells (by SV40 large T antigen) induced a decrease in sn-glycero-3-phosphocholine (GPCho), whereas H-ras alone, which is known to cause growth arrest in these cells, induced a marked increase in GPCho and a decrease in pho...
متن کاملConcepts in malignant transformation.
The precise biochemical nature of malignant transformation remains elusive. This article reviews some of the current theories of oncogenesis and aims to synthesize these concepts into a possible schema for the origins of malignant transformation, using a cell-programmed origin for neoplastic progression. It is proposed that cell transformation in malignancy is initiated by injury but finds ulti...
متن کاملCholine Metabolism: Meaning and Significance
Choline is an essential nutrient Choline (Cho), a quaternary amine, is an essential nutrient supplied by the diet (1, 2). Choline uptake and intracellular metabolism during the prenatal period were shown to have a critical role in brain development and cognitive processes (3, 4). Choline is a precursor in several key biochemical pathways as demonstrated below in scheme 1. Scheme 1: Metabolic Fa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2011
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc3162